Locking up & Slowwww.. Please Help

Hello,
I have a Windows 7 64-bit netbook that has become very unresponsive and so slow,
especially when I am on the internet / loading the browser/ trying to load pages/loading links
What I've done:
- Kaspersky is updated & running
- Ran Malwarebytes
- Spyblaster is updated & running
- Windows updates were installed
- Updated all outdated system drivers
- Installed and ran CCleaner (system backed up before use) No Change after running different cleanup options.

I am at a loss please help!